Anti-DNASE2 Antibody
Boster Bio Anti-DNASE2 Antibody catalog # A08512-1. Tested in WB, IHC, ICC, IF, IP, ELISA applications. This antibody reacts with Human, Mouse, Rat.
Product Specifications
Background
DNASE2, or 'acid DNase, ' hydrolyzes DNA under acidic conditions and is one of 2 distinct mammalian DNases. It hydrolyzes DNA under acidic conditions with a preference for double-stranded DNA. It has a key role in the degradation of nuclear DNA in cellular apoptosis during development [PMID:18812394]. Besieds, it is necessary for proper fetal development and for definitive erythropoiesis in fetal liver, where it degrades nuclear DNA expelled from erythroid precursor cells. It has been demonstrated to be responsible forDNA degradation in apoptotic cells engulfed by macrophages and exogenous DNA on the skin surface [PMID:23019102]. DNASE2 exists some isoforms with MV 39 and 34 kDa. (PMID: 14644493)
Synonyms
DNASE2A; DNase II alpha; Deoxyribonuclease-2-alpha; Deoxyribonuclease II alpha; Deoxyribonuclease 2 alpha
Gene Name
DNASE2
UniProt
O00115
Host
Rabbit
Reactivity
Human, Mouse, Rat
Immunogen
E.coli-derived human DNASE2 recombinant protein (Position: P3-Y358) .
Clonality
Polyclonal
Applications
WB, IHC, ICC, IF, IP, ELISA
Purification
Immunogen affinity purified.
Concentration
500 μg/mL
Form
Liquid
Storage Conditions
12 months from date of receipt, -20°C as supplied. 6 months 2 to 8°C after reconstitution. Avoid repeated freezing and thawing.
Gene Name Synonym
Deoxyribonuclease 2, lysosomal
Protein Name
Deoxyribonuclease-2-alpha
Contents
500 μg/mL antibody with PBS,0.02% NaN3, 1 mg BSA and 50% glycerol.
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