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Anti-NPLOC4 Antibody

Boster Bio Anti-NPLOC4 Antibody catalog # A08476. Tested in WB, ICC/IF applications. This antibody reacts with Human, Mouse, Rat.

Product Specifications

Synonyms

Nuclear protein localization protein 4 homolog; Protein NPL4; NPLOC4; KIAA1499, NPL4

Gene Name

NPLOC4

UniProt

Q8TAT6

Host

Rabbit

Reactivity

Human, Mouse, Rat

Immunogen

Recombinant fusion protein of human NPLOC4 (NP_060391.2) .

Clonality

Polyclonal

Tissue Specificity

Expressed at highest levels in brain, heart, skeletal muscle, kidney and fetal liver.

Applications

WB, ICC, IF

Purification

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .

Concentration

1 mg/mL

Form

Liquid

Function

The ternary complex containing UFD1, VCP and NPLOC4 binds ubiquitinated proteins and is necessary for the export of misfolded proteins from the ER to the cytoplasm, where they are degraded by the proteasome. The NPLOC4-UFD1-VCP complex regulates spindle disassembly at the end of mitosis and is necessary for the formation of a closed nuclear envelope (By similarity) . Acts as a negative regulator of type I interferon production via the complex formed with VCP and UFD1, which binds to DDX58/RIG-I and recruits RNF125 to promote ubiquitination and degradation of DDX58/RIG-I (PubMed:26471729) .

Storage Conditions

Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.

Observed Molecular Weight

68120 MW

Gene Name Synonym

Nuclear protein localization protein 4 homolog

Subcellular Location

Cytoplasm, cytosol

Protein Name

Nuclear protein localization protein 4 homolog

Contents

Rabbit IgG, 1mg/mL in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

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