Anti-HEMGN Antibody (C-term)
Boster Bio Anti-HEMGN Antibody (C-term) (Catalog # A08422) . Tested in WB application (s) . This antibody reacts with Human.
Product Specifications
Background
Regulates the proliferation and differentiation of hematopoietic cells. Overexpression block the TPA-induced megakaryocytic differentiation in the K562 cell model. May also prevent cell apoptosis through the activation of the nuclear factor-kappa B (NF-kB) .
Synonyms
Hemogen, Erythroid differentiation-associated gene protein, EDAG-1, Hemopoietic gene protein, Negative differentiation regulator protein, HEMGN, EDAG, NDR
Gene Name
HEMGN
UniProt
Q9BXL5
Host
Rabbit
Reactivity
Human
Immunogen
This HEMGN antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 355-389 amino acids from the C-terminal region of human HEMGN.
Clonality
Polyclonal
Tissue Specificity
Expressed in hematopoietic precursor cells, thyroid and spermatids (at protein level) . Expressed in bone marrow, testis, thymus. Expressed in prostate cancer and ovarian cancer. Also expressed in thymus and thyroid tumors, non-Hodgkin lymphoma, various leukemia cell lines, peripheral blood mononuclear cells (PBMCs) and bone marrow mononuclear cells (BMMCs) of patients with leukemia
Applications
WB
Field of Research
Signal Transduction, Stem Cells
Purification
This antibody is purified through a protein A column, followed by peptide affinity purification.
Function
Regulates the proliferation and differentiation of hematopoietic cells. Overexpression block the TPA-induced megakaryocytic differentiation in the K562 cell model. May also prevent cell apoptosis through the activation of the nuclear factor-kappa B (NF-kB) .
Storage Conditions
Maintain refrigerated at 2-8°C for up to 2 weeks. For long-term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
Observed Molecular Weight
55341 Da
Applications Notes
WB: 1:2000
Subcellular Location
Nucleus.
Isotype
Rabbit IgG
Contents
Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide.
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