Anti-p140Cap SRCIN1 Antibody
Boster Bio Anti-p140Cap SRCIN1 Antibody catalog # A08110. Tested in WB, ELISA applications. This antibody reacts with Human, Mouse, Rat.
Product Specifications
Synonyms
SRC kinase signaling inhibitor 1; SNAP-25-interacting protein; SNIP; p130Cas-associated protein; p140Cap; SRCIN1; KIAA1684, P140
Gene Name
SRCIN1
UniProt
Q9C0H9
Host
Rabbit
Reactivity
Human, Mouse, Rat
Immunogen
The antiserum was produced against synthesized peptide derived from human SNIP. AA range:811-860
Tissue Specificity
Expressed in some primary breast carcinomas where its presence is significantly associated with increased tumor size. Not detected in normal breast tissue. .
Applications
WB, ELISA
Purification
Immunogen affinity purified
Concentration
1 mg/mL
Form
Liquid
Function
Acts as a negative regulator of SRC by activating CSK which inhibits SRC activity and downstream signaling, leading to impaired cell spreading and migration. Regulates dendritic spine morphology. Involved in calcium-dependent exocytosis. May play a role in neurotransmitter release or synapse maintenance. .
Storage Conditions
Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.
Observed Molecular Weight
112453 MW
Gene Name Synonym
SRC kinase signaling inhibitor 1
Subcellular Location
Cytoplasm. Cytoplasm, cytoskeleton. Cell projection, axon . Cell projection, dendrite . Cell junction, synapse . Cell junction, synapse, postsynaptic cell membrane, postsynaptic density . Localized to the perinuclear region, lamellopodia, cortical actin and actin stress fibers but not to focal adhesions. Strongly expressed in axons and dendrites of the CA1 and CA3 hippocampal regions and of the dentate gyrus. Detected in both presynapses and postsynapses and in postsynaptic density fractions.
Isotype
IgG
Contents
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
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