Anti-Tryptase alpha/beta-1 TPSAB1 Antibody
Boster Bio Anti-Tryptase alpha/beta-1 TPSAB1 Antibody catalog # A08039. Tested in WB applications. This antibody reacts with Human, Mouse, Rat.
Product Specifications
Synonyms
Tryptase alpha/beta-1; Tryptase-1;3.4.21.59; Tryptase I; Tryptase alpha-1; TPSAB1; TPS1, TPS2, TPSB1
Gene Name
TPSAB1
UniProt
Q15661
Host
Rabbit
Reactivity
Human, Mouse, Rat
Immunogen
A synthetic peptide of human TPSAB1 (NP_003285.2) .
Clonality
Polyclonal
Tissue Specificity
Isoform 1 and isoform 2 are expressed in lung, stomach, spleen, heart and skin; in these tissues, isoform 1 is predominant. Isoform 2 is expressed in aorta, spleen, and breast tumor, with highest levels in the endothelial cells of some blood vessels surrounding the aorta, as well as those surrounding the tumor and low levels, if any, in mast cells (at protein level) .
Applications
WB
Purification
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .
Concentration
1 mg/mL
Form
Liquid
Function
Tryptase is the major neutral protease present in mast cells and is secreted upon the coupled activation-degranulation response of this cell type. May play a role in innate immunity. Isoform 2 cleaves large substrates, such as fibronectin, more efficiently than isoform 1, but seems less efficient toward small substrates (PubMed:18854315) .
Storage Conditions
Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.
Observed Molecular Weight
30515 MW
Applications Notes
WB: 1:500-1:2000
Gene Name Synonym
Tryptase alpha/beta-1
Subcellular Location
Secreted. Released from the secretory granules upon mast cell activation. .
Protein Name
Tryptase alpha/beta-1
Contents
Rabbit IgG, 1mg/mL in PBS with 0.02% sodium azide, 50% glycerol, pH7.2
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