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Anti-Tryptase alpha/beta-1 TPSAB1 Antibody

Boster Bio Anti-Tryptase alpha/beta-1 TPSAB1 Antibody catalog # A08039. Tested in WB applications. This antibody reacts with Human, Mouse, Rat.

Product Specifications

Synonyms

Tryptase alpha/beta-1; Tryptase-1;3.4.21.59; Tryptase I; Tryptase alpha-1; TPSAB1; TPS1, TPS2, TPSB1

Gene Name

TPSAB1

UniProt

Q15661

Host

Rabbit

Reactivity

Human, Mouse, Rat

Immunogen

A synthetic peptide of human TPSAB1 (NP_003285.2) .

Clonality

Polyclonal

Tissue Specificity

Isoform 1 and isoform 2 are expressed in lung, stomach, spleen, heart and skin; in these tissues, isoform 1 is predominant. Isoform 2 is expressed in aorta, spleen, and breast tumor, with highest levels in the endothelial cells of some blood vessels surrounding the aorta, as well as those surrounding the tumor and low levels, if any, in mast cells (at protein level) .

Applications

WB

Purification

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .

Concentration

1 mg/mL

Form

Liquid

Function

Tryptase is the major neutral protease present in mast cells and is secreted upon the coupled activation-degranulation response of this cell type. May play a role in innate immunity. Isoform 2 cleaves large substrates, such as fibronectin, more efficiently than isoform 1, but seems less efficient toward small substrates (PubMed:18854315) .

Storage Conditions

Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.

Product Datasheet

https://www.bosterbio.com/datasheet?sku=A08039

Product MSDS

https://www.bosterbio.com/msds?sku=A08039

Observed Molecular Weight

30515 MW

Applications Notes

WB: 1:500-1:2000

Gene Name Synonym

Tryptase alpha/beta-1

Subcellular Location

Secreted. Released from the secretory granules upon mast cell activation. .

Protein Name

Tryptase alpha/beta-1

Contents

Rabbit IgG, 1mg/mL in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

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