Anti-NOSIP Antibody
Boster Bio Anti-NOSIP Antibody catalog # A07558. Tested in WB applications. This antibody reacts with Human.
Product Specifications
Synonyms
Nitric oxide synthase-interacting protein; E3 ubiquitin-protein ligase NOSIP;2.3.2.27; RING-type E3 ubiquitin transferase NOSIP ; eNOS-interacting protein; NOSIP; CGI-25
Gene Name
NOSIP
UniProt
Q9Y314
Host
Rabbit
Reactivity
Human
Immunogen
Recombinant fusion protein of human NOSIP (NP_057037.1) .
Clonality
Polyclonal
Tissue Specificity
Expressed in heart, brain and lung. Present in endothelial cells (at protein level) .
Applications
WB
Purification
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .
Concentration
1 mg/mL
Form
Liquid
Function
E3 ubiquitin-protein ligase that is essential for proper development of the forebrain, the eye, and the face. Catalyzes monoubiquitination of serine/threonine-protein phosphatase 2A (PP2A) catalytic subunit PPP2CA/PPP2CB (By similarity) . Negatively regulates nitric oxide production by inducing NOS1 and NOS3 translocation to actin cytoskeleton and inhibiting their enzymatic activity (PubMed:11149895, PubMed:15548660, PubMed:16135813) .
Storage Conditions
Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.
Observed Molecular Weight
33172 MW
Applications Notes
WB: 1:500-1:2000
Gene Name Synonym
Nitric oxide synthase-interacting protein
Subcellular Location
Cytoplasm
Protein Name
Nitric oxide synthase-interacting protein
Contents
Rabbit IgG, 1mg/mL in PBS with 0.02% sodium azide, 50% glycerol, pH7.2
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