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Anti-TFIP11 Antibody (N-term)

Boster Bio Anti-TFIP11 Antibody (N-term) (Catalog # A07513-1) . Tested in IHC-P, WB application (s) . This antibody reacts with Human.

Product Specifications

Background

TFIP11 is a nuclear speckle-localized protein that may play a role in spliceosome disassembly in Cajal bodies (Stanek et al., 2008 [PubMed 18367544]) .

Synonyms

Tuftelin-interacting protein 11, Septin and tuftelin-interacting protein 1, STIP-1, TFIP11, STIP

Gene Name

TFIP11

UniProt

Q9UBB9

Host

Rabbit

Reactivity

Human

Immunogen

This TFIP11 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 42-70 amino acids from the N-terminal region of human TFIP11.

Clonality

Polyclonal

Applications

IHC-P, WB

Purification

This antibody is purified through a protein A column, followed by peptide affinity purification.

Function

Involved in pre-mRNA splicing, specifically in spliceosome disassembly during late-stage splicing events. Intron turnover seems to proceed through reactions in two lariat-intron associated complexes termed Intron Large (IL) and Intron Small (IS) . In cooperation with DHX15 seems to mediate the transition of the U2, U5 and U6 snRNP- containing IL complex to the snRNP-free IS complex leading to efficient debranching and turnover of excised introns. May play a role in the differentiation of ameloblasts and odontoblasts or in the forming of the enamel extracellular matrix.

Storage Conditions

Maintain refrigerated at 2-8°C for up to 2 weeks. For long-term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Product Datasheet

https://www.bosterbio.com/datasheet?sku=A07513-1

Product MSDS

https://www.bosterbio.com/msds?sku=A07513-1

Observed Molecular Weight

96820 Da

Subcellular Location

Cytoplasm. Nucleus. Note=In the nucleus localizes to unique speckle domains in close proximity to nuclear speckles and not identical to paraspeckles

Prediction Reactivity

Monkey

Isotype

Rabbit IgG

Contents

Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide.

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