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Anti-Protein JTB JTB Antibody

Boster Bio Anti-Protein JTB JTB Antibody catalog # A07448. Tested in WB, IHC applications. This antibody reacts with Human, Mouse, Rat.

Product Specifications

Synonyms

Protein JTB; Jumping translocation breakpoint protein; Prostate androgen-regulated protein; PAR protein; JTB; HSPC222

Gene Name

JTB

UniProt

O76095

Host

Rabbit

Reactivity

Human, Mouse, Rat

Immunogen

The antiserum was produced against synthesized peptide derived from human JTB. AA range:10-59

Tissue Specificity

Ubiquitous. Expressed in all normal human tissues studied but overexpressed or underexpressed in many of their malignant counterparts. .

Applications

WB, IHC

Purification

Immunogen affinity purified

Concentration

1 mg/mL

Form

Liquid

Function

Required for normal cytokinesis during mitosis. Plays a role in the regulation of cell proliferation. May be a component of the chromosomal passenger complex (CPC), a complex that acts as a key regulator of mitosis. The CPC complex has essential functions at the centromere in ensuring correct chromosome alignment and segregation and is required for chromatin-induced microtubule stabilization and spindle assembly. Increases AURKB activity. Inhibits apoptosis induced by TGFB1 (By similarity) . Overexpression induces swelling of mitochondria and reduces mitochondrial membrane potential (By similarity) . .

Storage Conditions

Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.

Observed Molecular Weight

16358 MW

Gene Name Synonym

Protein JTB

Subcellular Location

Membrane ; Single-pass type I membrane protein . Mitochondrion . Cytoplasm. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm, cytoskeleton, spindle. Detected at the centrosome and along spindle fibers during prophase and metaphase. Detected at the midbody during telophase.

Isotype

IgG

Contents

Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

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