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Anti-Protein orai-2 ORAI2 Antibody

Boster Bio Anti-Protein orai-2 ORAI2 Antibody (Catalog # A07411) . Tested in ELISA, WB, ICC, IF applications. This antibody reacts with Human, Mouse.

Product Specifications

Background

Antigen stimulation of immune cells triggers Ca++ entry through Ca++ release-activated Ca++ (CRAC) channels. ORAI2 is one of two mammalian homologs to ORAI1, a recently identified four-transmembrane spanning protein that is an essential component of CRAC. Like ORAI1, ORAI2 has been shown to function as a highly selective Ca++ plasma membrane channel that is gated through interactions with STIM1, the store-activated endoplasmic reticulum Ca++ sensor, although at a lesser efficacy than ORAI1.

Synonyms

CBCIP2, C7orf19, MEM142B, TMEM142B, CBCIP2, PP1729, Protein orai-2, CAP-binding protein complex-interacting protein 2

Gene Name

ORAI2

UniProt

Q96SN7

Host

Rabbit

Reactivity

Human, Mouse

Cross Reactivity

At least two isoforms of ORAI2 are known to exist; this antibody will detect both isoforms. ORAI antibody is predicted not to cross-react with ORAI1 or ORAI3.

Immunogen

ORAI2 antibody was raised against a 15 amino acid synthetic peptide from near the carboxy terminus of human ORAI2. The immunogen is located within the last 50 amino acids of ORAI2.

Clonality

Polyclonal

Tissue Specificity

Ubiquitously expressed in the adult brain.

Applications

ELISA, WB, ICC, IF

Field of Research

Immunology

Purification

ORAI2 Antibody is affinity chromatography purified via peptide column.

Concentration

1 mg/mL

Form

Liquid

Function

Ca (2+) release-activated Ca (2+) -like (CRAC-like) channel subunit which mediates Ca (2+) influx and increase in Ca (2+) - selective current by synergy with the Ca (2+) sensor, STIM1.

Storage Conditions

ORAI2 antibody can be stored at 4°C for three months and -20°C, stable for up to one year. Avoid repeated freeze-thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Observed Molecular Weight

28570 MW

Gene Name Synonym

ORAI calcium release-activated calcium modulator 2

Subcellular Location

Membrane ; Multi-pass membrane protein .

Prediction Reactivity

Chicken

Protein Name

ORAI calcium release-activated calcium modulator 2

Isotype

IgG

Contents

ORAI2 Antibody is supplied in PBS containing 0.02% sodium azide.

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