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Anti-DHB12 HSD17B12 Antibody

Boster Bio Anti-DHB12 HSD17B12 Antibody catalog # A07397. Tested in WB, ELISA applications. This antibody reacts with Human, Mouse, Rat.

Product Specifications

Synonyms

Very-long-chain 3-oxoacyl-CoA reductase ;1.1.1.330

Gene Name

HSD17B12

UniProt

Q53GQ0

Host

Rabbit

Reactivity

Human, Mouse, Rat

Immunogen

Synthesized peptide derived from part region of human protein

Clonality

Polyclonal

Tissue Specificity

Expressed in most tissues tested. Highly expressed in the ovary and mammary. Expressed in platelets.

Applications

WB, ELISA

Purification

DHB12 antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration

1 mg/mL

Form

Liquid

Function

Catalyzes the second of the four reactions of the long- chain fatty acids elongation cycle. This endoplasmic reticulum- bound enzymatic process, allows the addition of two carbons to the chain of long- and very long-chain fatty acids/VLCFAs per cycle. This enzyme has a 3-ketoacyl-CoA reductase activity, reducing 3- ketoacyl-CoA to 3-hydroxyacyl-CoA, within each cycle of fatty acid elongation. Thereby, it may participate in the production of VLCFAs of different chain lengths that are involved in multiple biological processes as precursors of membrane lipids and lipid mediators. May also catalyze the transformation of estrone (E1) into estradiol (E2) and play a role in estrogen formation.

Storage Conditions

Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.

Observed Molecular Weight

34324 MW

Gene Name Synonym

Very-long-chain 3-oxoacyl-CoA reductase

Subcellular Location

Endoplasmic reticulum membrane

Protein Name

Very-long-chain 3-oxoacyl-CoA reductase

Isotype

IgG

Contents

Liquid form in PBS containing 50% glycerol, and 0.02% sodium azide.

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