Anti-MBTPS2 Antibody
Boster Bio Anti-MBTPS2 Antibody catalog # A07369. Tested in WB applications. This antibody reacts with Human, Mouse.
Product Specifications
Synonyms
Membrane-bound transcription factor site-2 protease;3.4.24.85; Endopeptidase S2P; Sterol regulatory element-binding proteins intramembrane protease; SREBPs intramembrane protease; MBTPS2; S2P
Gene Name
MBTPS2
UniProt
O43462
Host
Rabbit
Reactivity
Human, Mouse
Immunogen
A synthetic peptide corresponding to residues in Human MBTPS2.
Clonality
Polyclonal
Tissue Specificity
Expressed in heart, brain, placenta, lung, liver, muscle, kidney and pancreas.
Applications
WB
Purification
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .
Concentration
1 mg/mL
Form
Liquid
Function
Involved in regulated intramembrane proteolysis (RIP) that is the cleavage of membrane-spanning regulatory proteins by proteases within the plane of the membrane. It cleaves sterol- regulatory element-binding proteins (SREBPs) within the first transmembrane segment, thereby releasing the N-terminal segment with a portion of the transmembrane segment attached. Mature N- terminal fragments shuttle to the nucleus and activate gene transcription (PubMed:9659902, PubMed:27380894) . Involved in RIP- mediated regulation of bone formation (PubMed:27380894) .
Storage Conditions
Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.
Observed Molecular Weight
57444 MW
Applications Notes
WB: 1:500-1:1000
Gene Name Synonym
Membrane-bound transcription factor site-2 protease
Subcellular Location
Membrane
Protein Name
Membrane-bound transcription factor site-2 protease
Contents
Rabbit IgG, 1mg/mL in PBS with 0.02% sodium azide, 50% glycerol, pH7.2
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