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Anti-CIR Antibody (N-term)

Boster Bio Anti-CIR Antibody (N-term) (Catalog # A07268) . Tested in WB application (s) . This antibody reacts with Human.

Product Specifications

Background

CIR may modulate splice site selection during alternative splicing of pre-mRNAs. It fegulates transcription and acts as corepressor for RBPSUH. It recruits RBPSUH to the Sin3-histone deacetylase complex (HDAC) and is required for RBPSUH-mediated repression of transcription.

Synonyms

Corepressor interacting with RBPJ 1, CBF1-interacting corepressor, Recepin, CIR1, CIR

Gene Name

CIR1

UniProt

Q86X95

Host

Rabbit

Reactivity

Human

Immunogen

This CIR antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 60-88 amino acids from the N-terminal region of human CIR.

Clonality

Polyclonal

Tissue Specificity

Highly expressed in heart, brain, placenta, liver, skeletal muscle and pancreas.

Applications

WB

Purification

This antibody is purified through a protein A column, followed by peptide affinity purification.

Function

May modulate splice site selection during alternative splicing of pre-mRNAs (By similarity) . Regulates transcription and acts as corepressor for RBPJ. Recruits RBPJ to the Sin3-histone deacetylase complex (HDAC) . Required for RBPJ-mediated repression of transcription.

Storage Conditions

Maintain refrigerated at 2-8°C for up to 2 weeks. For long-term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Observed Molecular Weight

52313 Da

Applications Notes

WB: 1:1000

Subcellular Location

Nucleus speckle. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Note=Colocalizes with NEK6 in the centrosome

Isotype

Rabbit IgG

Contents

Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide.

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