Anti-DNA helicase MCM9 MCM9 Antibody

Component of the MCM8-MCM9 complex, a complex involved in the repair of double-stranded DNA breaks (DBSs) and DNA interstrand cross-links (ICLs) by homologous recombination (HR) (PubMed:23401855) . Required for DNA resection by the MRE11-RAD50- NBN/NBS1 (MRN) complex by recruiting the MRN complex to the repair site and by promoting the complex nuclease activity (PubMed:26215093) . Probably by regulating the localization of the MRN complex, indirectly regulates the recruitment of downstream effector RAD51 to DNA damage sites including DBSs and ICLs (PubMed:23401855) . Acts as an helicase in DNA mismatch repair (MMR) following DNA replication errors to unwind the mismatch containing DNA strand (PubMed:26300262) . In addition, recruits MLH1, a component of the MMR complex, to chromatin (PubMed:26300262) . The MCM8-MCM9 complex is dispensable for DNA replication and S phase progression (PubMed:23401855) . Probably by regulating HR, plays a key role during gametogenesis (By similarity) .