Anti-Collectin-12 COLEC12 Antibody
Boster Bio Anti-Collectin-12 COLEC12 Antibody catalog # A07213. Tested in WB applications. This antibody reacts with Human, Mouse.
Product Specifications
Synonyms
Collectin-12; Collectin placenta protein 1; CL-P1; hCL-P1; Nurse cell scavenger receptor 2; Scavenger receptor class A member 4; Scavenger receptor with C-type lectin; COLEC12; CLP1, NSR2, SCARA4, SRCL
Gene Name
COLEC12
UniProt
Q5KU26
Host
Rabbit
Reactivity
Human, Mouse
Immunogen
Recombinant fusion protein of human COLEC12 (NP_569057.1) .
Clonality
Polyclonal
Tissue Specificity
Expressed in perivascular macrophages. Expressed in plaques-surrounding reactive astrocytes and in perivascular astrocytes associated with cerebral amyloid angiopathy (CAA) in the temporal cortex of Alzheimer patient (at protein level) . Strongly expressed in placenta. Moderately expressed in heart, skeletal muscle, small intestine and lung. Weakly expressed in brain, colon, thymus and kidney. Expressed in nurse-like cells. Expressed in reactive astrocytes and vascular/perivascular cells in the brain of Alzheimer patient.
Applications
WB
Purification
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .
Concentration
1 mg/mL
Form
Liquid
Function
Scavenger receptor that displays several functions associated with host defense. Promotes binding and phagocytosis of Gram-positive, Gram-negative bacteria and yeast. Mediates the recognition, internalization and degradation of oxidatively modified low density lipoprotein (oxLDL) by vascular endothelial cells. Binds to several carbohydrates including Gal-type ligands, D-galactose, L- and D-fucose, GalNAc, T and Tn antigens in a calcium-dependent manner and internalizes specifically GalNAc in nurse-like cells. Binds also to sialyl Lewis X or a trisaccharide and asialo-orosomucoid (ASOR) . May also play a role in the clearance of amyloid-beta in Alzheimer disease.
Storage Conditions
Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.
Observed Molecular Weight
81515 MW
Applications Notes
WB: 1:500-1:2000
Gene Name Synonym
Collectin-12
Subcellular Location
Membrane
Protein Name
Collectin-12
Contents
Rabbit IgG, 1mg/mL in PBS with 0.02% sodium azide, 50% glycerol, pH7.2
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