Anti-APEX2 Antibody (Center)

Boster Bio Anti-APEX2 Antibody (Center) (Catalog # A07203-2) . Tested in WB, IF, Flow Cytometry, IHC-P application (s) . This antibody reacts with Human.

Product Specifications

Background

APEX2 may participate in both nuclear and mitochondrial post-replicative base excision repair (BER) . In the nucleus functions in the PCNA-dependent BER pathway.

Synonyms

DNA- (apurinic or apyrimidinic site) lyase 2, 31--, AP endonuclease XTH2, APEX nuclease 2, APEX nuclease-like 2, Apurinic-apyrimidinic endonuclease 2, AP endonuclease 2, APEX2, APE2, APEXL2, XTH2

Gene Name

APEX2

UniProt

Q9UBZ4

Host

Rabbit

Reactivity

Human

Immunogen

This APEX2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 143-171 amino acids from the Central region of human APEX2.

Clonality

Polyclonal

Tissue Specificity

Highly expressed in brain and kidney. Weakly expressed in the fetal brain.

Applications

WB, IF, Flow Cytometry, IHC-P

Field of Research

Mitochondria

Purification

This antibody is purified through a protein A column, followed by peptide affinity purification.

Function

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Storage Conditions

Maintain refrigerated at 2-8°C for up to 2 weeks. For long-term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Observed Molecular Weight

57401 Da

Subcellular Location

Nucleus {ECO:0000255|PROSITE-ProRule:PRU00764, ECO:0000269|PubMed:11376153, ECO:0000269|PubMed:19443450}. Cytoplasm Mitochondrion. Note=Together with PCNA, is redistributed in discrete nuclear foci in presence of oxidative DNA damaging agents.