Anti-NIPA ZC3HC1 Antibody
Boster Bio Anti-NIPA ZC3HC1 Antibody catalog # A07135. Tested in WB, IF, ELISA applications. This antibody reacts with Human, Mouse, Rat, Monkey.
Product Specifications
Synonyms
Nuclear-interacting partner of ALK; Nuclear-interacting partner of anaplastic lymphoma kinase; hNIPA; Zinc finger C3HC-type protein 1; ZC3HC1; NIPA; HSPC216
Gene Name
ZC3HC1
UniProt
Q86WB0
Host
Rabbit
Reactivity
Human, Mouse, Rat, Monkey
Immunogen
The antiserum was produced against synthesized peptide derived from human NIPA. AA range:320-369
Tissue Specificity
Widely expressed. Highly expressed in heart, skeletal muscle and testis. Expressed in brain, placenta, lung, kidney, liver, pancreas, spleen, thymus, prostate, ovary small intestine and colon. Weakly or not expressed in leukocytes. .
Applications
WB, IF, ELISA
Purification
Immunogen affinity purified
Concentration
1 mg/mL
Form
Liquid
Function
Essential component of an SCF-type E3 ligase complex, SCF (NIPA), a complex that controls mitotic entry by mediating ubiquitination and subsequent degradation of cyclin B1 (CCNB1) . Its cell-cycle-dependent phosphorylation regulates the assembly of the SCF (NIPA) complex, restricting CCNB1 ubiquitination activity to interphase. Its inactivation results in nuclear accumulation of CCNB1 in interphase and premature mitotic entry. May have an antiapoptotic role in NPM-ALK-mediated signaling events. .
Storage Conditions
Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.
Observed Molecular Weight
55262 MW
Gene Name Synonym
Nuclear-interacting partner of ALK
Subcellular Location
Nucleus .
Isotype
IgG
Contents
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
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