Anti-RNF40 Antibody
Boster Bio Anti-RNF40 Antibody catalog # A06979. Tested in WB, IHC applications. This antibody reacts with Human.
Product Specifications
Synonyms
E3 ubiquitin-protein ligase BRE1B; BRE1-B;2.3.2.27
Gene Name
RNF40
UniProt
O75150
Host
Rabbit
Reactivity
Human
Immunogen
Recombinant fusion protein of human RNF40 (NP_055586.1) .
Clonality
Polyclonal
Tissue Specificity
Ubiquitously expressed. Expressed at higher level in testis, heart and pancreas, while it is only weakly expressed in lung, skeletal muscle and small intestine.
Applications
WB, IHC
Purification
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .
Concentration
1 mg/mL
Form
Liquid
Function
Component of the RNF20/40 E3 ubiquitin-protein ligase complex that mediates monoubiquitination of 'Lys-120' of histone H2B (H2BK120ub1) . H2BK120ub1 gives a specific tag for epigenetic transcriptional activation and is also prerequisite for histone H3 'Lys-4' and 'Lys-79' methylation (H3K4me and H3K79me, respectively) . It thereby plays a central role in histone code and gene regulation. The RNF20/40 complex forms a H2B ubiquitin ligase complex in cooperation with the E2 enzyme UBE2A or UBE2B; reports about the cooperation with UBE2E1/UBCH are contradictory. Required for transcriptional activation of Hox genes.
Storage Conditions
Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.
Observed Molecular Weight
113678 MW
Gene Name Synonym
E3 ubiquitin-protein ligase BRE1B
Subcellular Location
Nucleus
Protein Name
E3 ubiquitin-protein ligase BRE1B
Contents
Rabbit IgG, 1mg/mL in PBS with 0.02% sodium azide, 50% glycerol, pH7.2
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