Anti-ATP6AP1 Antibody
Boster Bio Anti-ATP6AP1 Antibody catalog # A06742. Tested in WB applications. This antibody reacts with Human, Mouse, Rat.
Product Specifications
Synonyms
V-type proton ATPase subunit S1; V-ATPase subunit S1; Protein XAP-3; V-ATPase Ac45 subunit; V-ATPase S1 accessory protein; Vacuolar proton pump subunit S1; ATP6AP1; ATP6IP1, ATP6S1, VATPS1, XAP3
Gene Name
ATP6AP1
UniProt
Q15904
Host
Rabbit
Reactivity
Human, Mouse, Rat
Immunogen
A synthetic peptide corresponding to residues in Human ATP6AP1.
Clonality
Polyclonal
Tissue Specificity
Widely expressed, with highest levels in brain and lowest in liver and duodenum.
Applications
WB
Purification
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .
Concentration
1 mg/mL
Form
Liquid
Function
Accessory subunit of the proton-transporting vacuolar (V) -ATPase protein pump, which is required for luminal acidification of secretory vesicles. Guides the V-type ATPase into specialized subcellular compartments, such as neuroendocrine regulated secretory vesicles or the ruffled border of the osteoclast, thereby regulating its activity. Involved in membrane trafficking and Ca (2+) -dependent membrane fusion. May play a role in the assembly of the V-type ATPase complex. In aerobic conditions, involved in intracellular iron homeostasis, thus triggering the activity of Fe (2+) prolyl hydroxylase (PHD) enzymes, and leading to HIF1A hydroxylation and subsequent proteasomal degradation (PubMed:28296633) .
Storage Conditions
Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.
Observed Molecular Weight
52026 MW
Applications Notes
WB: 1:500-1:1000
Gene Name Synonym
V-type proton ATPase subunit S1
Subcellular Location
Endoplasmic reticulum membrane
Protein Name
V-type proton ATPase subunit S1
Contents
Rabbit IgG, 1mg/mL in PBS with 0.02% sodium azide, 50% glycerol, pH7.2
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