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Anti-PIK3R3 Antibody (C-term)

Boster Bio Anti-PIK3R3 Antibody (C-term) (Catalog # A06707-1) . Tested in IF, WB, IHC-P application (s) . This antibody reacts with Human.

Product Specifications

Background

PIK3R3 binds to activated (phosphorylated) protein-tyrosine kinases through its SH2 domain and regulates their kinase activity. During insulin stimulation, it also binds to IRS-1. It is a component of a heterodimer of p110 (catalytic) and p55 (regulatory) subunits. The protein is expressed at highest levels in brain and testis. Lower levels are detected in adipose tissue, kidney, heart, lung and skeletal muscle. The protein contains 2 SH2 domains.

Synonyms

Phosphatidylinositol 3-kinase regulatory subunit gamma, PI3-kinase regulatory subunit gamma, PI3K regulatory subunit gamma, PtdIns-3-kinase regulatory subunit gamma, Phosphatidylinositol 3-kinase 55 kDa regulatory subunit gamma, PI3-kinase subunit p55-gamma, PtdIns-3-kinase regulatory subunit p55-gamma, p55PIK, PIK3R3

Gene Name

PIK3R3

UniProt

Q92569

Host

Rabbit

Reactivity

Human

Immunogen

This PIK3R3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 316-346 amino acids from the C-terminal region of human PIK3R3.

Clonality

Polyclonal

Tissue Specificity

Highest levels in brain and testis. Lower levels in adipose tissue, kidney, heart, lung and skeletal muscle

Applications

IF, WB, IHC-P

Field of Research

Cancer, Immunology, Signal Transduction, TLR Signaling, T Cells, Chemokine signaling, Apoptosis

Purification

This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.

Function

Binds to activated (phosphorylated) protein-tyrosine kinases through its SH2 domain and regulates their kinase activity. During insulin stimulation, it also binds to IRS-1.

Storage Conditions

Maintain refrigerated at 2-8°C for up to 2 weeks. For long-term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Observed Molecular Weight

54448 Da

Isotype

Rabbit IgG

Contents

Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide.

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