Anti-TLK2 Antibody
Boster Bio Anti-TLK2 Antibody catalog # A06645-2. Tested in WB, IHC, ICC/IF, ELISA applications. This antibody reacts with Human, Mouse, Rat.
Product Specifications
Background
Tousled-like kinases (TLKs) are a family of serine/threonine kinases located in the nucleus that promote S-phase chromatin assembly and mitotic chromosome segregation. There are two genes in the TLK family-TLK1 and TLK2 (PMID: 14561777) . Mutation in TLK2 are associated with an elevated risk of breast cancer (PMID: 27489360) . Tousled-like kinase 2 (TLK2) is a key factor in glioblastoma that modulates SRC signaling, thereby driving tumor malignancy. TLK2 is commonly upregulated in glioblastoma, and such upregulation was associated with poor patient outcomes. TLK2 overexpression induced cell growth, migration, invasion, and epithelialmesenchymal transition, and cell cycle arrest, while TLK2 knockdown had the opposite effect (PMID: 30207834) . It can detect 3 isoforms of 88, 85 and 82 kDa.
Gene Name
TLK2
UniProt
Q86UE8
Host
Rabbit
Reactivity
Human, Mouse, Rat
Immunogen
E.coli-derived human TLK2 recombinant protein (Position: P514-S828) .
Clonality
Polyclonal
Applications
WB, IHC, ICC/IF, ELISA
Purification
Immunogen affinity purified.
Concentration
500 μg/mL
Form
Liquid
Storage Conditions
12 months from date of receipt, -20°C as supplied. 6 months 2 to 8°C after reconstitution. Avoid repeated freezing and thawing.
Product Datasheet
https://www.bosterbio.com/datasheet?sku=A06645-2
Product MSDS
https://www.bosterbio.com/datasheet?sku=A06645-2
Contents
500 μg/mL antibody with PBS,0.02% NaN3, 1 mg BSA and 50% glycerol.
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