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Anti-TIM-4 TIMD4 Antibody

Boster Bio Anti-TIM-4 TIMD4 Antibody (Catalog # A06637) . Tested in ELISA, WB applications. This antibody reacts with Human, Mouse, Rat.

Product Specifications

Background

The T cell immunoglobulin and mucin domain containing protein (TIM) family encodes cell surface receptors that are involved in the regulation of T helper (Th) -1 and -2 cell-mediated immunity. TIM-4, which is preferentially expressed on macrophages and dendritic cells, is the natural ligand of TIM-1, and this binding leads to T-cell expansion and cytokine production. Unlike other members of the TIM family, TIM-4 lacks a putative tyrosine phosphorylation signal sequence in its intracellular domain. The TIM-4 gene maps to a locus associated with predisposition to asthma in both mice and humans and with its connection to TIM-1-triggered Th2 responsiveness, may be considered as a candidate disease/predisposition gene for asthma.

Synonyms

TIM4, SMUCKLER, TIM4, T-cell immunoglobulin and mucin domain-containing protein 4, T-cell immunoglobulin mucin receptor 4, TIMD-4

Gene Name

TIMD4

UniProt

Q96H15

Host

Rabbit

Reactivity

Human, Mouse, Rat

Immunogen

TIM-4 antibody was raised against a 15 amino acid synthetic peptide from near the carboxy terminus of human TIM-4. The immunogen is located within the last 50 amino acids of TIM-4.

Clonality

Polyclonal

Tissue Specificity

Widely expressed, with highest levels in kidney and testis. Expressed by activated CD4+ T-cells during the development of helper T-cells responses.

Applications

ELISA, WB

Field of Research

Immunology, Growth Factors, Signal Transduction, Neuroscience

Purification

TIM-4 Antibody is affinity chromatography purified via peptide column.

Concentration

1 mg/mL

Form

Liquid

Function

Phosphatidylserine receptor that enhances the engulfment of apoptotic cells. Involved in regulating T-cell proliferation and lymphotoxin signaling. Ligand for HAVCR1/TIMD1 (By similarity) . .

Storage Conditions

TIM-4 antibody can be stored at 4°C for three months and -20°C, stable for up to one year. Avoid repeated freeze-thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Product Datasheet

https://www.bosterbio.com/datasheet?sku=A06637

Product MSDS

https://www.bosterbio.com/msds?sku=A06637

Observed Molecular Weight

41578 MW

Gene Name Synonym

T-cell immunoglobulin and mucin domain containing 4

Subcellular Location

Membrane ; Single-pass type I membrane protein .

Protein Name

T-cell immunoglobulin and mucin domain containing 4

Isotype

IgG

Contents

TIM-4 Antibody is supplied in PBS containing 0.02% sodium azide.

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