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Anti-MAPE Antibody (C-term)

Boster Bio Anti-MAPE Antibody (C-term) (Catalog # A06628-1) . Tested in IHC-P, WB, Flow Cytometry application (s) . This antibody reacts with Human.

Product Specifications

Background

MAPE is an antigen that is predominantly expressed in human melanomas and that is recognized by cytolytic T lymphocytes. It is not expressed in normal tissues, except testis. This expression pattern is similar to that of other CT antigens, such as MAGE, BAGE and GAGE. However, unlike these other CT antigens, its gene is also expressed in acute leukemias.

Synonyms

Melanoma antigen preferentially expressed in tumors, Opa-interacting protein 4, OIP-4, Preferentially expressed antigen of melanoma, PRAME, MAPE, OIP4

Gene Name

PRAME

UniProt

P78395

Host

Rabbit

Reactivity

Human

Immunogen

This MAPE antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 476-502 amino acids from the C-terminal region of human MAPE.

Clonality

Polyclonal

Tissue Specificity

Expressed in testis. Detected in samples of kidney, brain and skin.

Applications

IHC-P, WB, Flow Cytometry

Field of Research

Cancer

Purification

This antibody is purified through a protein A column, followed by peptide affinity purification.

Function

2182221526138980261389802182221516179254

Storage Conditions

Maintain refrigerated at 2-8°C for up to 2 weeks. For long-term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Product Datasheet

https://www.bosterbio.com/datasheet?sku=A06628-1

Product MSDS

https://www.bosterbio.com/msds?sku=A06628-1

Observed Molecular Weight

57890 Da

Subcellular Location

Nucleus. Chromosome. Cytoplasm Golgi apparatus. Cell membrane. Note=Associates with chromatin; specifically enriched at transcriptionally active promoters that are also bound by nuclear transcription factor Y (composed of NFYA, NFYB and NFYC) and at enhancers (PubMed:21822215) . Recruited to the Golgi apparatus in response to interferon gamma (IFNG) treatment (PubMed:23460923) .

Isotype

Rabbit IgG

Contents

Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide.

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