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Anti-RapGEF1/Grf2 Antibody

Boster Bio Anti-RapGEF1/Grf2 Antibody (Catalog# A06527) . Tested in IHC, ICC, IF, ELISA applications. This antibody reacts with Human, Mouse, Rat.

Product Specifications

Synonyms

RAPGEF1; GRF2; Rap guanine nucleotide exchange factor 1; CRK SH3-binding GNRP; Guanine nucleotide-releasing factor 2; Protein C3G

Gene Name

RAPGEF1

UniProt

Q13905

Host

Rabbit

Reactivity

Human, Mouse, Rat

Immunogen

A peptide derived from human RAPGEF1. Immunogen sequence location: 470-519

Clonality

Polyclonal

Tissue Specificity

Ubiquitously expressed in adult and fetus. Expression is high in adult skeletal muscle and placenta and in fetal brain and heart. Low levels of expression in adult and fetal liver.

Applications

IHC, ICC, IF, ELISA

Field of Research

G Protein Signaling, Ras Family, Regulators, Signal Transduction, Signaling Pathway, Small G Proteins

Purification

The antibody was purified from rabbit antiserum by affinity-chromatography using immunogen.

Concentration

0.5-1mg/mL, actual concentration vary by lot. Use suggested dilution ratio to decide dilution procedure.

Form

Liquid

Function

Guanine nucleotide-releasing protein that binds to SH3 domain of CRK and GRB2/ASH. Transduces signals from CRK to activate RAS. Plays a role in the establishment of basal endothelial barrier function. Plays a role in nerve growth factor (NGF) -induced sustained activation of Rap1 and neurite outgrowth.

Storage Conditions

Store at -20°C for one year. For short-term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.

Observed Molecular Weight

120548 MW

Gene Name Synonym

Rap guanine nucleotide exchange factor 1

Subcellular Location

Early endosome.

Isotype

Rabbit IgG

Contents

PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

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