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Anti-CISD2 Antibody

Boster Bio Anti-CISD2 Antibody (Catalog # A06387) . Tested in ELISA, WB, IHC-P, IF applications. This antibody reacts with Human, Mouse, Rat.

Product Specifications

Background

Defects in the CISD2 (CDGSH iron sulfur domain 2) gene are a cause of the neurodegenerative disorder Wolfram syndrome 2. CISD2 is a zinc finger protein that localizes to the endoplasmic reticulum and mitochondria and binds an iron/sulfur cluster. CISD2 interacts with Bcl-2 and can be displaced by the BH3-only protein BIK and contributes to the regulation of BIK-initiated autophagy. CISD2 deficiency in mice causes mitochondrial breakdown accompanied by autophagic cell death as well as the development of premature aging phenotype.

Synonyms

ERIS, WFS2, ZCD2, NAF-1, Miner1, CDGSH2, ERIS, CDGSH iron-sulfur domain-containing protein 2, Endoplasmic reticulum intermembrane small protein

Gene Name

CISD2

UniProt

Q8N5K1

Host

Rabbit

Reactivity

Human, Mouse, Rat

Immunogen

CISD2 antibody was raised against a 15 amino acid peptide near the center of human CISD2. The immunogen is located within amino acids 40 - 90 of CISD2.

Clonality

Polyclonal

Tissue Specificity

Testis, small intestine, kidney, lung, brain, heart, pancreas and platelets.

Applications

ELISA, WB, IHC-P, IF

Field of Research

Autophagy

Purification

CISD2 Antibody is affinity chromatography purified via peptide column.

Concentration

1 mg/mL

Form

Liquid

Function

Regulator of autophagy that contributes to antagonize BECN1-mediated cellular autophagy at the endoplasmic reticulum. Participates in the interaction of BCL2 with BECN1 and is required for BCL2-mediated depression of endoplasmic reticulum Ca (2+) stores during autophagy. Contributes to BIK-initiated autophagy, while it is not involved in BIK-dependent activation of caspases. Involved in life span control, probably via its function as regulator of autophagy.

Storage Conditions

CISD2 antibody can be stored at 4°C for three months and -20°C, stable for up to one year.

Observed Molecular Weight

15278 MW

Gene Name Synonym

CDGSH iron sulfur domain 2

Subcellular Location

Endoplasmic reticulum membrane; Single-pass membrane protein. Mitochondrion outer membrane; Single-pass membrane protein. According to PubMed:20010695, it mainly localizes to the endoplasmic reticulum. However, experiments in mouse showed that it mainly localizes to the mitochondrion outer membrane.

Prediction Reactivity

Bovine

Protein Name

CDGSH iron sulfur domain 2

Isotype

IgG

Contents

CISD2 Antibody is supplied in PBS containing 0.02% sodium azide.

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