Anti-Mouse Srms Antibody (Center)
Boster Bio Anti-Mouse Srms Antibody (Center) (Catalog # A06352-1) . Tested in WB, IF application (s) . This antibody reacts with Mouse.
Product Specifications
Background
Non-receptor tyrosine-protein kinase which phosphorylates DOK1 on tyrosine residues. May be involved in proliferation or differentiation of keratinocytes in the skin.
Synonyms
Tyrosine-protein kinase Srms, PTK70, Srms, Srm
Gene Name
Srms
UniProt
Q62270
Host
Rabbit
Reactivity
Mouse
Immunogen
This Mouse Srms antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 113-147 amino acids from the Central region of Mouse Srms.
Clonality
Polyclonal
Tissue Specificity
Higher expression in liver, lung, thymus and skin than in brain, kidney, heart and spleen (PubMed:9226137) . In skin, highly expressed in keratinocytes (PubMed:9226137) . Abundant in lung, liver, spleen, kidney and testis and is also detected in the cerebrum (PubMed:7935409) .
Applications
WB, IF
Field of Research
Signal Transduction
Purification
This antibody is purified through a protein A column, followed by peptide affinity purification.
Function
Non-receptor tyrosine-protein kinase which phosphorylates DOK1 on tyrosine residues. Also phosphorylates KHDRBS1/SAM68 and VIM on tyrosine residues. Phosphorylation of KHDRBS1 is EGF-dependent. Phosphorylates OTUB1, promoting deubiquitination of RPTOR.
Storage Conditions
Maintain refrigerated at 2-8°C for up to 2 weeks. For long-term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
Observed Molecular Weight
55758 Da
Subcellular Location
Cytoplasm {ECO:0000250|UniProtKB:Q9H3Y6}. Note=Localizes to punctate cytoplasmic structures {ECO:0000250|UniProtKB:Q9H3Y6}
Isotype
Rabbit IgG
Contents
Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide.
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