Anti-Paraspeckle component 1 PSPC1 Antibody
Boster Bio Anti-Paraspeckle component 1 PSPC1 Antibody catalog # A06348. Tested in WB, IHC, IP applications. This antibody reacts with Human, Mouse, Rat.
Product Specifications
Synonyms
Paraspeckle component 1; Paraspeckle protein 1; PSPC1; PSP1
Gene Name
PSPC1
UniProt
Q8WXF1
Host
Rabbit
Reactivity
Human, Mouse, Rat
Immunogen
Recombinant fusion protein of human PSPC1 (NP_001035879.1) .
Clonality
Polyclonal
Tissue Specificity
Expressed in pancreas, kidney, skeletal muscle, liver, lung, placenta, brain and heart.
Applications
WB, IHC, IP
Purification
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .
Concentration
1 mg/mL
Form
Liquid
Function
Regulates, cooperatively with NONO and SFPQ, androgen receptor-mediated gene transcription activity in Sertoli cell line (By similarity) . Binds to poly (A), poly (G) and poly (U) RNA homopolymers. Regulates the circadian clock by repressing the transcriptional activator activity of the CLOCK-ARNTL/BMAL1 heterodimer (By similarity) . Together with NONO, required for the formation of nuclear paraspeckles. Plays a role in the regulation of DNA virus-mediated innate immune response by assembling into the HDP-RNP complex, a complex that serves as a platform for IRF3 phosphorylation and subsequent innate immune response activation through the cGAS-STING pathway.
Storage Conditions
Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.
Observed Molecular Weight
58744 MW
Gene Name Synonym
Paraspeckle component 1
Subcellular Location
Nucleus, nucleolus. Nucleus matrix . Cytoplasm . Nucleus speckle. In punctate subnuclear structures often located adjacent to splicing speckles, called paraspeckles. Colocalizes with NONO and SFPQ in paraspeckles and perinucleolar caps in an RNA-dependent manner. May cycle between paraspeckles and nucleolus. In telophase, when daughter nuclei form, localizes to perinucleolar caps.
Protein Name
Paraspeckle component 1
Contents
Rabbit IgG, 1mg/mL in PBS with 0.02% sodium azide, 50% glycerol, pH7.2
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