Anti-GPM6A Antibody (C-term)
Boster Bio Anti-GPM6A Antibody (C-term) (Catalog # A06295-1) . Tested in WB, Flow Cytometry application (s) . This antibody reacts with Human.
Product Specifications
Synonyms
Neuronal membrane glycoprotein M6-a, M6a, GPM6A, M6A
Gene Name
GPM6A
UniProt
P51674
Host
Rabbit
Reactivity
Human
Immunogen
This GPM6A antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 232-259 amino acids from the C-terminal region of human GPM6A.
Clonality
Polyclonal
Applications
WB, Flow Cytometry
Field of Research
Neuroscience
Purification
This antibody is purified through a protein A column, followed by peptide affinity purification.
Function
Involved in neuronal differentiation, including differentiation and migration of neuronal stem cells. Plays a role in neuronal plasticity and is involved in neurite and filopodia outgrowth, filopodia motility and probably synapse formation. GPM6A-induced filopodia formation involves mitogen-activated protein kinase (MAPK) and Src signaling pathways. May be involved in neuronal NGF-dependent Ca (2+) influx. May be involved in regulation of endocytosis and intracellular trafficking of G-protein-coupled receptors (GPCRs) ; enhances internalization and recycling of mu-type opioid receptor.
Storage Conditions
Maintain refrigerated at 2-8°C for up to 2 weeks. For long-term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
Observed Molecular Weight
31210 Da
Subcellular Location
Cell membrane {ECO:0000250|UniProtKB:P35802}; Multi-pass membrane protein {ECO:0000250|UniProtKB:P35802}. Cell projection, axon {ECO:0000250|UniProtKB:P35802}. Cell projection, growth cone {ECO:0000250|UniProtKB:P35802}. Cell projection, dendritic spine {ECO:0000250|UniProtKB:Q812E9}. Cell projection, filopodium {ECO:0000250|UniProtKB:Q812E9}. Cell projection, neuron projection {ECO:0000250|UniProtKB:Q812E9}. Note=Localizes to cholesterol-rich lipid rafts of the plasma membrane of hippocampal neurons. Localized to plasma membrane of cell bodies and neurites of hippocampal neurons Localized in membrane protrusions (filopodia and spines) of primary hippocampal neurons (By similarity) . Localized to the growth cone edge membrane of elongating axons (By similarity) {ECO:0000250|UniProtKB:P35802, ECO:0000250|UniProtKB:Q812E9}
Prediction Reactivity
Bovine, Mouse, Rat
Isotype
Rabbit IgG
Contents
Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide.
Curated Selection
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