Anti-NAT10 Antibody

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .

RNA cytidine acetyltransferase with specificity toward both 18S rRNA and tRNAs (PubMed:25411247, PubMed:25653167) . Catalyzes the formation of N (4) -acetylcytidine (ac4C) at position 1842 in 18S rRNA (PubMed:25411247) . May also catalyze the formation of ac4C at position 1337 in 18S rRNA (By similarity) . Required for early nucleolar cleavages of precursor rRNA at sites A0, A1 and A2 during 18S rRNA synthesis (PubMed:25411247, PubMed:25653167) . Catalyzes the formation of ac4C in serine and leucine tRNAs (By similarity) . Requires the tRNA-binding adapter protein THUMBD1 for full tRNA acetyltransferase activity but not for 18S rRNA acetylation (PubMed:25653167) . Can acetylate both histones and microtubules (PubMed:14592445, PubMed:17631499, PubMed:19303003) . Histone acetylation may regulate transcription and mitotic chromosome de-condensation (PubMed:17631499) . Activates telomerase activity by stimulating the transcription of TERT, and may also regulate telomerase function by affecting the balance of telomerase subunit assembly, disassembly, and localization (PubMed:14592445, PubMed:18082603) . Acetylates alpha- tubulin, which may affect microtubule stability and cell division (PubMed:19303003) .