Anti-DNA helicase MCM8 MCM8 Antibody

Highest levels in placenta, lung and pancreas. Low levels in skeletal muscle and kidney. Expressed in various tumors with highest levels in colon and lung cancers.

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .

Component of the MCM8-MCM9 complex, a complex involved in the repair of double-stranded DNA breaks (DBSs) and DNA interstrand cross-links (ICLs) by homologous recombination (HR) (PubMed:23401855) . Required for DNA resection by the MRE11-RAD50- NBN/NBS1 (MRN) complex by recruiting the MRN complex to the repair site and by promoting the complex nuclease activity (PubMed:26215093) . Probably by regulating the localization of the MNR complex, indirectly regulates the recruitment of downstream effector RAD51 to DNA damage sites including DBSs and ICLs (PubMed:23401855) . The MCM8-MCM9 complex is dispensable for DNA replication and S phase progression (PubMed:23401855) . However, may play a non-essential for DNA replication: may be involved in the activation of the prereplicative complex (pre-RC) during G (1) phase by recruiting CDC6 to the origin recognition complex (ORC) (PubMed:15684404) . Probably by regulating HR, plays a key role during gametogenesis (By similarity) . Stabilizes MCM9 protein (PubMed:23401855, PubMed:26215093) .