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Anti-TNFAIP1 Antibody

Boster Bio Anti-TNFAIP1 Antibody (Catalog # A06143) . Tested in ELISA, WB, IHC-P, IF applications. This antibody reacts with Human, Mouse, Rat.

Product Specifications

Background

TNFAIP1 is a BTB/POZ domain-containing protein that belongs to the KCTD10/BACURD family which mediates POZ-POZ interactions and chromatin modeling (1,2) . The expression of TNFAIP1 is developmentally regulated in a tissue-specific manner and can be induced by the tumor necrosis factor alpha (TNF) in umbilical vein endothelial cells (3) . TNFAIP1 may be involved in DNA repair, DNA synthesis, and cell apoptosis. TNFAIP1 is suggested to play a role in the process of cancer and in the innate immunity against the Hepatitis B virus (4,5) .

Synonyms

Tumor necrosis factor, alpha-induced protein 1, BTB/POZ domain-containing protein TNFAIP1, BTB/POZ domain-containing adapter for CUL3-mediated RhoA degradation protein 2, BACURD2, EDP1

Gene Name

TNFAIP1

UniProt

Q13829

Host

Rabbit

Reactivity

Human, Mouse, Rat

Cross Reactivity

TNFAIP1 antibody is human, mouse and rat reactive. TNFAIP1 antibody is predicted to not cross-react with other TNFAIP proteins.

Immunogen

TNFAIP1 antibody was raised against a 19 amino acid peptide from near the carboxy terminus of human TNFAIP1. The immunogen is located within the last 50 amino acids of TNFAIP1.

Clonality

Polyclonal

Applications

ELISA, WB, IHC-P, IF

Field of Research

Apoptosis, Cancer, Innate Immunity

Purification

TNFAIP1 Antibody is affinity chromatography purified via peptide column.

Concentration

1 mg/mL

Form

Liquid

Function

Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex involved in regulation of cytoskeleton structure. The BCR (TNFAIP1) E3 ubiquitin ligase complex mediates the ubiquitination of RHOA, leading to its degradation by the proteasome, thereby regulating the actin cytoskeleton and cell migration. Its interaction with RHOB may regulate apoptosis. May enhance the PCNA-dependent DNA polymerase delta activity.

Storage Conditions

TNFAIP1 antibody can be stored at 4°C for three months and -20°C, stable for up to one year.

Observed Molecular Weight

36204 MW

Gene Name Synonym

Tumor necrosis factor, alpha-induced protein 1 (endothelial)

Subcellular Location

Cytoplasm. Nucleus. Endosome. Colocalizes with RHOB in endosomes.

Prediction Reactivity

Chicken

Protein Name

Tumor necrosis factor, alpha-induced protein 1 (endothelial)

Isotype

IgG

Contents

TNFAIP1 Antibody is supplied in PBS containing 0.02% sodium azide.

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