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Anti-Morc3 Antibody

Boster Bio Anti-Morc3 Antibody (Catalog # A06075) . Tested in WB applications. This antibody reacts with Human, Mouse.

Product Specifications

Background

The Morc (microrchidia) family of proteins are ATPases of the GHKL family. They have been implicated in transcriptional repression of genes and transposons, and higher order organization of DNA within the nucleus. Morc antibodies are ideal for researchers interested in Epigenetics, Cancer, and Cell cycle research.

Synonyms

Morc3, MORC family CW-type zinc finger protein 3, Protein microrchidia, Morc, Nuclear matrix protein 2, Zinc finger CW-type coiled-coil domain protein 3, ZCWCC3, NXP2

Gene Name

MORC3

UniProt

Q14149

Host

Rabbit

Reactivity

Human, Mouse

Immunogen

Morc3 whole rabbit serum was prepared by repeated immunizations with a human Morc3 recombinant protein.

Clonality

Polyclonal

Tissue Specificity

Expressed in heart, placenta, skeletal muscle, brain, pancreas, lung, liver, but not kidney.

Applications

ELISA, WB

Field of Research

Cell Cycle, Cell Cycle Inhibitors, Chromatin Binding Proteins, DNA/RNA Binding, Epigenetics and Nuclear Signaling

Purification

Morc3 antibody was prepared from monospecific antiserum by delipidation and defibrination. The antibody is specific for human Morc3 in expressed cell lysates. Cross-reactivity is seen in mouse Morc3. Cross-reactivity to other Morc proteins has not been determined.

Concentration

70 mg/mL by Refractometry

Form

Liquid (sterile filtered)

Function

Nuclear factor which forms MORC3-NBs (nuclear bodies) via an ATP-dependent mechanism (PubMed:20501696) . Sumoylated MORC3-NBs can also associate with PML-NBs (PubMed:20501696) . Recruits TP53 and SP100 to PML-NBs, thus regulating TP53 activity (PubMed:17332504) . Binds RNA in vitro (PubMed:11927593) . May be required for influenza A transcription during viral infection (PubMed:26202233) .

Shipping Conditions

Dry Ice Shipping

Storage Conditions

Store vial at -20°C prior to opening. Aliquot contents and freeze at -20°C or below for extended storage. Avoid cycles of freezing and thawing. Centrifuge product if not completely clear after standing at room temperature. This product is stable for several weeks at 4°C as an undiluted liquid. Dilute only prior to immediate use. Expiration date is one (1) year from date of opening.

Observed Molecular Weight

107113 MW

Gene Name Synonym

MORC family CW-type zinc finger protein 3

Subcellular Location

Nucleus, nucleoplasm. Nucleus matrix. Nucleus, PML body. Also found in PML-independent nuclear bodies. Localization to nuclear bodies is ATP-dependent.

Isotype

Antiserum

Contents

0.02 M Potassium Phosphate, 0.15 M Sodium Chloride, pH 7.2, 0.01% (w/v) Sodium Azide

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