Anti-ITPKB Antibody

Inositol 1,4,5-trisphosphate 3-kinase isoform B (IITPKB) is also named as IP3KB and possesses important roles in the development of immune cells. IP3KB can be targeted to multiple cellular compartments, among them nuclear localization and binding in close proximity to the plasma membrane. The B isoform is the only IP3K that is almost ubiquitously expressed in mammalian cells (PMID:21148483) .Three isoforms of IP3KB occur in mammals, which are distinguished by different molecular masses, sensitivity to Ca2+/CaM (calmodulin), intracellular distribution and tissue expression (PMID:16173920) . ITPKB can be cleaved into many fragments, this antibody can recognize the N-terminal peptide fragment. (PMID:15130091)