Anti-Cyclin T2/CCNT2 Antibody
Boster Bio Anti-Cyclin T2/CCNT2 Antibody catalog # A06015-2. Tested in WB, IHC, ELISA applications. This antibody reacts with Human, Mouse, Rat.
Product Specifications
Background
Cyclin T2 (CCNT2) belongs to the cyclin family. CCNT2 is regulatory subunit of the cyclin-dependent kinase pair (CDK9/cyclin T) complex, also called positive transcription elongation factor B (P-TEFB), which is proposed to facilitate the transition from abortive to production elongation by phosphorylating the CTD (carboxy-terminal domain) of the large subunit of RNA polymerase II (RNAP II) (PMID: 9499409, PMID: 15563843) . Cyclin T2 is expressed at a relatively high level in freshly isolated monocytes and its level remains constant when the cells are induced to undergo macrophage differentiation (PMID: 21791050) . In contrast, Cyclin T1 is expressed at low levels in monocytes and it is strongly up-regulated by a post-transcriptional mechanism when the cells are induced to differentiate to macrophages.
Gene Name
CCNT2
UniProt
O60583
Host
Rabbit
Reactivity
Human, Mouse, Rat
Immunogen
E.coli-derived human Cyclin T2/CCNT2 recombinant protein (Position: K253-S607) .
Clonality
Polyclonal
Applications
WB, IHC, ELISA
Purification
Immunogen affinity purified.
Concentration
500 μg/mL
Form
Liquid
Storage Conditions
12 months from date of receipt, -20°C as supplied. 6 months 2 to 8°C after reconstitution. Avoid repeated freezing and thawing.
Contents
500 μg/mL antibody with PBS,0.02% NaN3, 1 mg BSA and 50% glycerol.
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