Anti-FCRL4 Antibody (C-term)

This gene encodes a member of the immunoglobulin receptor superfamily and is one of several Fc receptor-like glycoproteins clustered on the long arm of chromosome 1. The encoded protein has four extracellular C2-type immunoglobulin domains, a transmembrane domain and a cytoplasmic domain that contains three immune-receptor tyrosine-based inhibitory motifs. This protein may play a role in the function of memory B-cells in the epithelia. Aberrations in the chromosomal region encoding this gene are associated with non-Hodgkin lymphoma and multiple myeloma.

Fc receptor-like protein 4, FcR-like protein 4, FcRL4, Fc receptor homolog 4, FcRH4, IFGP family protein 2, hIFGP2, Immune receptor translocation-associated protein 1, CD307d, FCRL4, FCRH4, IFGP2, IRTA1

This FCRL4 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 480-507 amino acids from the C-terminal region of human FCRL4.

Specifically expressed by memory and monocytoid B- cells which populate spleen and lymph nodes. Preferentially expressed in memory B-cells associated with mucosal tissue (at protein level)