Anti-WNT5 WNT5B Antibody
Boster Bio Anti-WNT5 WNT5B Antibody (Catalog # A05836) . Tested in ELISA, WB, IHC-P applications. This antibody reacts with Human, Mouse, Rat.
Product Specifications
Background
WNT5A and WNT5B are near-identical members of the WNT gene family, which consists of structurally related genes which encode secreted signaling proteins that have been implicated in oncogenesis and in several developmental processes, including regulation of cell fate and patterning during embryogenesis (1,2) . WNT5A and WNT5B coordinate chondrocyte proliferation and differentiation by differentially regulating cyclin D1 and p130 expression, as well as chondrocyte-specific Col2a1 expression (3) . Up-regulation of WNT5A and WNT5B has been observed in several types of human cancers, suggesting that they may be useful as diagnostic markers or potent therapeutic targets (4) .
Synonyms
Wingless-type MMTV integration site family member 5
Gene Name
WNT5B
UniProt
Q9H1J7
Host
Rabbit
Reactivity
Human, Mouse, Rat
Cross Reactivity
WNT5 antibody is human, mouse and rat reactive. WNT5 antibody will detect both WNT5A and WNT5B. At least two isoforms of WNT5B are known to exist; this antibody will detect both isoforms.
Immunogen
WNT5 antibody was raised against a 15 amino acid peptide near the center of human WNT5B. The immunogen is located within amino acids 130 - 180 of WNT5.
Clonality
Polyclonal
Applications
ELISA, WB, IHC-P
Field of Research
Cancer, Cell Cycle, Stem Cells
Purification
WNT5 antibody is affinity chromatography purified via peptide column.
Concentration
1 mg/mL
Form
Liquid
Function
Ligand for members of the frizzled family of seven transmembrane receptors. Probable developmental protein. May be a signaling molecule which affects the development of discrete regions of tissues. Is likely to signal over only few cell diameters (By similarity) . .
Storage Conditions
WNT5 antibody can be stored at 4°C for three months and -20°C, stable for up to one year.
Observed Molecular Weight
40323 MW
Gene Name Synonym
Wnt family member 5B
Subcellular Location
Secreted, extracellular space, extracellular matrix.
Prediction Reactivity
Rabbit
Protein Name
Wnt family member 5B
Isotype
IgG
Contents
WNT5 antibody is supplied in PBS containing 0.02% sodium azide.
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