Anti-Cyclin-C CCNC Antibody
Boster Bio Anti-Cyclin-C CCNC Antibody catalog # A05832. Tested in WB, IHC applications. This antibody reacts with Human, Mouse, Rat.
Product Specifications
Synonyms
Cyclin-C; SRB11 homolog; hSRB11; CCNC
Gene Name
CCNC
UniProt
P24863
Host
Rabbit
Reactivity
Human, Mouse, Rat
Immunogen
Recombinant fusion protein of human Cyclin C (NP_005181.2) .
Clonality
Polyclonal
Tissue Specificity
Highest levels in pancreas. High levels in heart, liver, skeletal muscle and kidney. Low levels in brain.
Applications
WB, IHC
Purification
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .
Concentration
1 mg/mL
Form
Liquid
Function
Component of the Mediator complex, a coactivator involved in regulated gene transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. Binds to and activates cyclin-dependent kinase CDK8 that phosphorylates the CTD (C-terminal domain) of the large subunit of RNA polymerase II (RNAp II), which may inhibit the formation of a transcription initiation complex.
Storage Conditions
Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.
Observed Molecular Weight
33243 MW
Gene Name Synonym
Cyclin-C
Subcellular Location
Nucleus .
Protein Name
Cyclin-C
Contents
Rabbit IgG, 1mg/mL in PBS with 0.02% sodium azide, 50% glycerol, pH7.2
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