Anti-Proto-oncogene DBL MCF2 Antibody
Boster Bio Anti-Proto-oncogene DBL MCF2 Antibody catalog # A05775. Tested in WB applications. This antibody reacts with Human, Mouse.
Product Specifications
Synonyms
Proto-oncogene DBL; Proto-oncogene MCF-2; MCF2-transforming protein; DBL-transforming protein; MCF2; DBL
Gene Name
MCF2
UniProt
P10911
Host
Rabbit
Reactivity
Human, Mouse
Immunogen
Recombinant fusion protein of human MCF2 (NP_001165347.1) .
Clonality
Polyclonal
Tissue Specificity
Isoform 1 is expressed only in brain. Isoform 3 is expressed in heart, kidney, spleen, liver and testis. Isoform 4 is expressed in brain, heart, kidney, testis, placenta, stomach and peripheral blood. The protein is detectable in brain, heart, kidney, intestine, muscle, lung and testis.
Applications
WB
Purification
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .
Concentration
1 mg/mL
Form
Liquid
Function
Guanine nucleotide exchange factor (GEF) that modulates the Rho family of GTPases. Promotes the conversion of some member of the Rho family GTPase from the GDP-bound to the GTP-bound form. Isoform 1 exhibits no activity toward RHOA, RAC1 or CDC42. Isoform 2 exhibits decreased GEF activity toward CDC42. Isoform 3 exhibits a weak but significant activity toward RAC1 and CDC42. Isoform 4 exhibits significant activity toward RHOA and CDC42. The truncated DBL oncogene is active toward RHOA, RAC1 and CDC42.
Storage Conditions
Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.
Observed Molecular Weight
107673 MW
Applications Notes
WB: 1:500-1:2000
Gene Name Synonym
Proto-oncogene DBL
Subcellular Location
Cytoplasm
Protein Name
Proto-oncogene DBL
Contents
Rabbit IgG, 1mg/mL in PBS with 0.02% sodium azide, 50% glycerol, pH7.2
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