Anti-Symplekin SYMPK Antibody
Boster Bio Anti-Symplekin SYMPK Antibody catalog # A05709. Tested in WB applications. This antibody reacts with Human, Mouse.
Product Specifications
Synonyms
Symplekin; SYMPK; SPK
Gene Name
SYMPK
UniProt
Q92797
Host
Rabbit
Reactivity
Human, Mouse
Immunogen
Recombinant fusion protein of human SYMPK (NP_004810.2) .
Clonality
Polyclonal
Tissue Specificity
In testis, expressed in polar epithelia and Sertoli cells but not in vascular endothelia. The protein is detected in stomach, duodenum, pancreas, liver, fetal brain, carcinomas, lens-forming cells, fibroblasts, lymphocytes, lymphoma cells, erythroleukemia cells but not in endothelium of vessels, epidermis, intercalated disks, Purkinje fiber cells of the heart and lymph node.
Applications
WB
Purification
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .
Concentration
1 mg/mL
Form
Liquid
Function
Scaffold protein that functions as a component of a multimolecular complex involved in histone mRNA 3'-end processing. Specific component of the tight junction (TJ) plaque, but might not be an exclusively junctional component. May have a house- keeping rule. Is involved in pre-mRNA polyadenylation. Enhances SSU72 phosphatase activity.
Storage Conditions
Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.
Observed Molecular Weight
141148 MW
Applications Notes
WB: 1:200-1:2000
Gene Name Synonym
Symplekin
Subcellular Location
Cytoplasm, cytoskeleton. Cell junction, tight junction. Cell membrane; Peripheral membrane protein; Cytoplasmic side. Cell junction. Nucleus, nucleoplasm. Cytoplasmic face of adhesion plaques (major) and nucleoplasm (minor) (in cells with TJ) . Nucleoplasm (in cells without TJ) . Nuclear bodies of heat-stressed cells. Colocalizes with HSF1 in nuclear stress bodies upon heat shock (PubMed:14707147) .
Protein Name
Symplekin
Contents
Rabbit IgG, 1mg/mL in PBS with 0.02% sodium azide, 50% glycerol, pH7.2
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