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Anti-NHP2 Antibody

Boster Bio Anti-NHP2 Antibody catalog # A05665. Tested in WB applications. This antibody reacts with Human, Rat.

Product Specifications

Synonyms

H/ACA ribonucleoprotein complex subunit 2; Nucleolar protein family A member 2; snoRNP protein NHP2; NHP2; NOLA2; HSPC286

Gene Name

NHP2

UniProt

Q9NX24

Host

Rabbit

Reactivity

Human, Rat

Immunogen

Recombinant fusion protein of human NHP2 (NP_060308.1) .

Clonality

Polyclonal

Tissue Specificity

Expressed in brain, colon, heart, kidney, ovary, pancreas, placenta, prostate, skeletal muscle, small intestine, spleen, testis and thymus. Also expressed at lower levels in the liver.

Applications

WB

Purification

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .

Concentration

1 mg/mL

Form

Liquid

Function

Required for ribosome biogenesis and telomere maintenance. Part of the H/ACA small nucleolar ribonucleoprotein (H/ACA snoRNP) complex, which catalyzes pseudouridylation of rRNA. This involves the isomerization of uridine such that the ribose is subsequently attached to C5, instead of the normal N1. Each rRNA can contain up to 100 pseudouridine ("psi") residues, which may serve to stabilize the conformation of rRNAs. May also be required for correct processing or intranuclear trafficking of TERC, the RNA component of the telomerase reverse transcriptase (TERT) holoenzyme.

Storage Conditions

Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.

Observed Molecular Weight

17201 MW

Applications Notes

WB: 1:500-1:2000

Gene Name Synonym

H/ACA ribonucleoprotein complex subunit 2

Subcellular Location

Nucleus, nucleolus. Nucleus, Cajal body. Also localized to Cajal bodies (coiled bodies) .

Protein Name

H/ACA ribonucleoprotein complex subunit 2

Contents

Rabbit IgG, 1mg/mL in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

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