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Anti-PDK3 Antibody

Boster Bio Anti-PDK3 Antibody catalog # A05658. Tested in WB applications. This antibody reacts with Human, Mouse, Rat.

Product Specifications

Synonyms

[Pyruvate dehydrogenase (acetyl-transferring) ] kinase isozyme 3, mitochondrial;2.7.11.2; Pyruvate dehydrogenase kinase isoform 3; PDK3; PDHK3

Gene Name

PDK3

UniProt

Q15120

Host

Rabbit

Reactivity

Human, Mouse, Rat

Immunogen

Recombinant fusion protein of human PDK3 (NP_005382.1) .

Clonality

Polyclonal

Tissue Specificity

Expressed in heart, skeletal muscle, spinal cord, as well as fetal and adult brain.

Applications

WB

Purification

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .

Concentration

1 mg/mL

Form

Liquid

Function

Inhibits pyruvate dehydrogenase activity by phosphorylation of the E1 subunit PDHA1, and thereby regulates glucose metabolism and aerobic respiration. Can also phosphorylate PDHA2. Decreases glucose utilization and increases fat metabolism in response to prolonged fasting, and as adaptation to a high-fat diet. Plays a role in glucose homeostasis and in maintaining normal blood glucose levels in function of nutrient levels and under starvation. Plays a role in the generation of reactive oxygen species.

Storage Conditions

Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.

Observed Molecular Weight

46939 MW

Applications Notes

WB: 1:500-1:2000

Gene Name Synonym

[Pyruvate dehydrogenase (acetyl-transferring) ] kinase isozyme 3, mitochondrial

Subcellular Location

Mitochondrion matrix.

Protein Name

[Pyruvate dehydrogenase (acetyl-transferring) ] kinase isozyme 3, mitochondrial

Contents

Rabbit IgG, 1mg/mL in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

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