Anti-SIVA SIVA1 Antibody
Boster Bio Anti-SIVA SIVA1 Antibody (Catalog # A05419) . Tested in ELISA, WB, IF applications. This antibody reacts with Human, Mouse.
Product Specifications
Background
SIVA plays an important role in the apoptotic pathway induced by the CD27 antigen, a member of the tumor necrosis factor receptor (TFNR) superfamily. SIVA is a small cysteine-rich protein with a unique N-terminal amphipathic helical region, a death domain homology region (DDHR) and a C-terminal cysteine-rich B-box-like or zinc-finger-like structure. The DDHR domain binds to CD27 and induces apoptosis in T cells through a caspase-dependent mitochondrial pathway. SIVA inhibits BCL2L1 isoform Bcl-xL anti-apoptotic activity and inhibits activation of NFκ-B and promotes T-cell receptor-mediated apoptosis. SIVA represents a potential therapeutic target for the treatment of neuronal cell death diseases.
Synonyms
SIVA, CD27BP, Siva-1, Siva-2, SIVA, Apoptosis regulatory protein Siva, CD27-binding protein
Gene Name
SIVA1
UniProt
O15304
Host
Chicken
Reactivity
Human, Mouse
Immunogen
SIVA antibody was raised against a 16 amino acid synthetic peptide near the amino terminus of human SIVA. The immunogen is located within the first 50 amino acids of SIVA.
Clonality
Polyclonal
Tissue Specificity
Ubiquitous. Mostly expressed in thymus, testis, ovary, prostate, small intestine and spleen and less in colon.
Applications
ELISA, WB, IF
Field of Research
Apoptosis
Purification
SIVA Antibody is affinity chromatography purified via peptide column.
Concentration
1 mg/mL
Form
Liquid
Function
Induces CD27-mediated apoptosis. Inhibits BCL2L1 isoform Bcl-x (L) anti-apoptotic activity. Inhibits activation of NF-kappa- B and promotes T-cell receptor-mediated apoptosis.
Storage Conditions
SIVA antibody can be stored at 4°C for three months and -20°C, stable for up to one year. Avoid repeated freeze-thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Observed Molecular Weight
18695 MW
Gene Name Synonym
SIVA1, apoptosis-inducing factor
Subcellular Location
Cytoplasm
Prediction Reactivity
Rat
Protein Name
SIVA1, apoptosis-inducing factor
Isotype
IgY
Contents
SIVA Antibody is supplied in PBS containing 0.02% sodium azide.
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