Anti-CNOT8 Antibody
Boster Bio Anti-CNOT8 Antibody catalog # A05401. Tested in WB applications. This antibody reacts with Human, Mouse.
Product Specifications
Synonyms
CCR4-NOT transcription complex subunit 8;3.1.13.4; CAF1-like protein; CALIFp; CAF2; CCR4-associated factor 8; Caf1b; CNOT8; CALIF, POP2
Gene Name
CNOT8
UniProt
Q9UFF9
Host
Rabbit
Reactivity
Human, Mouse
Immunogen
Recombinant fusion protein of human CNOT8 (NP_004770.4) .
Clonality
Polyclonal
Applications
WB
Purification
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .
Concentration
1 mg/mL
Form
Liquid
Function
Has 3'-5' poly (A) exoribonuclease activity for synthetic poly (A) RNA substrate. Its function seems to be partially redundant with that of CNOT7. Catalytic component of the CCR4-NOT complex which is linked to various cellular processes including bulk mRNA degradation, miRNA-mediated repression, translational repression during translational initiation and general transcription regulation. During miRNA-mediated repression the complex seems also to act as translational repressor during translational initiation. Additional complex functions may be a consequence of its influence on mRNA expression. Associates with members of the BTG family such as TOB1 and BTG2 and is required for their anti-proliferative activity.
Storage Conditions
Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.
Observed Molecular Weight
33540 MW
Applications Notes
WB: 1:500-1:2000
Gene Name Synonym
CCR4-NOT transcription complex subunit 8
Subcellular Location
Cytoplasm
Protein Name
CCR4-NOT transcription complex subunit 8
Contents
Rabbit IgG, 1mg/mL in PBS with 0.02% sodium azide, 50% glycerol, pH7.2
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