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Anti-CNOT8 Antibody

Boster Bio Anti-CNOT8 Antibody catalog # A05401. Tested in WB applications. This antibody reacts with Human, Mouse.

Product Specifications

Synonyms

CCR4-NOT transcription complex subunit 8;3.1.13.4; CAF1-like protein; CALIFp; CAF2; CCR4-associated factor 8; Caf1b; CNOT8; CALIF, POP2

Gene Name

CNOT8

UniProt

Q9UFF9

Host

Rabbit

Reactivity

Human, Mouse

Immunogen

Recombinant fusion protein of human CNOT8 (NP_004770.4) .

Clonality

Polyclonal

Applications

WB

Purification

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .

Concentration

1 mg/mL

Form

Liquid

Function

Has 3'-5' poly (A) exoribonuclease activity for synthetic poly (A) RNA substrate. Its function seems to be partially redundant with that of CNOT7. Catalytic component of the CCR4-NOT complex which is linked to various cellular processes including bulk mRNA degradation, miRNA-mediated repression, translational repression during translational initiation and general transcription regulation. During miRNA-mediated repression the complex seems also to act as translational repressor during translational initiation. Additional complex functions may be a consequence of its influence on mRNA expression. Associates with members of the BTG family such as TOB1 and BTG2 and is required for their anti-proliferative activity.

Storage Conditions

Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.

Observed Molecular Weight

33540 MW

Applications Notes

WB: 1:500-1:2000

Gene Name Synonym

CCR4-NOT transcription complex subunit 8

Subcellular Location

Cytoplasm

Protein Name

CCR4-NOT transcription complex subunit 8

Contents

Rabbit IgG, 1mg/mL in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

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