Anti-MAGE-C2 Antibody
Boster Bio Anti-MAGE-C2 Antibody catalog # A05335. Tested in WB, ELISA applications. This antibody reacts with Human.
Product Specifications
Synonyms
Melanoma-associated antigen C2; Cancer/testis antigen 10; CT10; Hepatocellular carcinoma-associated antigen 587; MAGE-C2 antigen; MAGE-E1 antigen; MAGEC2; HCA587, MAGEE1
Gene Name
MAGEC2
UniProt
Q9UBF1
Host
Rabbit
Reactivity
Human
Immunogen
Synthesized peptide derived from MAGE-C2 . at AA range: 160-240
Tissue Specificity
Not expressed in normal tissues, except in germ cells in the seminiferous tubules and in Purkinje cells of the cerebellum. Expressed in various tumors, including melanoma, lymphoma, as well as pancreatic cancer, mammary gland cancer, non- small cell lung cancer and liver cancer. In hepatocellular carcinoma, there is a inverse correlation between tumor differentiation and protein expression, i.e. the lower the differentiation, the higher percentage of expression. .
Applications
WB, ELISA
Purification
Immunogen affinity purified
Concentration
1 mg/mL
Form
Liquid
Function
Proposed to enhance ubiquitin ligase activity of RING- type zinc finger-containing E3 ubiquitin-protein ligases. In vitro enhances ubiquitin ligase activity of TRIM28 and stimulates p53/TP53 ubiquitination in presence of Ubl-conjugating enzyme UBE2H leading to p53/TP53 degradation. Proposed to act through recruitment and/or stabilization of the Ubl-conjugating enzymes (E2) at the E3:substrate complex. .
Storage Conditions
Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.
Observed Molecular Weight
41163 MW
Gene Name Synonym
Melanoma-associated antigen C2
Subcellular Location
Cytoplasm . Nucleus . Nuclear in germ cells. Cytoplasmic in well-differentiated hepatocellular carcinoma, nuclear in moderately- and poorly-differentiated hepatocellular carcinoma.
Isotype
IgG
Contents
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
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