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Anti-PDE8A Antibody

Boster Bio Anti-PDE8A Antibody catalog # A05304. Tested in WB applications. This antibody reacts with Mouse, Rat.

Product Specifications

Synonyms

High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A;3.1.4.53

Gene Name

PDE8A

UniProt

O60658

Host

Rabbit

Reactivity

Mouse, Rat

Immunogen

Recombinant fusion protein of human PDE8A (NP_002596.1) .

Clonality

Polyclonal

Tissue Specificity

Expressed in most tissues except thymus and peripheral blood leukocytes. Highest levels in testis, ovary, small intestine and colon.

Applications

WB

Purification

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .

Concentration

1 mg/mL

Form

Liquid

Function

Hydrolyzes the second messenger cAMP, which is a key regulator of many important physiological processes (PubMed:18983167) . May be involved in maintaining basal levels of the cyclic nucleotide and/or in the cAMP regulation of germ cell development (PubMed:18983167) . Binding to RAF1 reduces RAF1 'Ser- 259' inhibitory-phosphorylation and stimulates RAF1-dependent EGF- activated ERK-signaling (PubMed:23509299) . Protects against cell death induced by hydrogen peroxide and staurosporine (PubMed:23509299) .

Storage Conditions

Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.

Observed Molecular Weight

93304 MW

Applications Notes

WB: 1:500-1:2000

Gene Name Synonym

High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A

Protein Name

High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A

Contents

Rabbit IgG, 1mg/mL in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

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