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Anti-Cyclin-dependent kinase 13 CDK13 Antibody

Boster Bio Anti-Cyclin-dependent kinase 13 CDK13 Antibody catalog # A05292. Tested in WB, ELISA applications. This antibody reacts with Human, Mouse.

Product Specifications

Synonyms

Cyclin-dependent kinase 13;2.7.11.22;2.7.11.23; CDC2-related protein kinase 5; Cell division cycle 2-like protein kinase 5; Cell division protein kinase 13; hCDK13; Cholinesterase-related cell division controller; CDK13; CDC2L, CDC2L5, CHED, KIAA1791

Gene Name

CDK13

UniProt

Q14004

Host

Rabbit

Reactivity

Human, Mouse

Immunogen

Synthesized peptide derived from human protein at AA range: 650-730

Clonality

Polyclonal

Tissue Specificity

Expressed in fetal brain, liver, muscle and in adult brain. Also expressed in neuroblastoma and glioblastoma tumors.

Applications

WB, ELISA

Purification

CDK13 antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration

1 mg/mL

Form

Liquid

Function

Cyclin-dependent kinase which displays CTD kinase activity and is required for RNA splicing. Has CTD kinase activity by hyperphosphorylating the C-terminal heptapeptide repeat domain (CTD) of the largest RNA polymerase II subunit RPB1, thereby acting as a key regulator of transcription elongation. Required for RNA splicing, probably by phosphorylating SRSF1/SF2. Required during hematopoiesis. In case of infection by HIV-1 virus, interacts with HIV-1 Tat protein acetylated at 'Lys-50' and 'Lys- 51', thereby increasing HIV-1 mRNA splicing and promoting the production of the doubly spliced HIV-1 protein Nef.

Storage Conditions

Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.

Observed Molecular Weight

164923 MW

Gene Name Synonym

Cyclin-dependent kinase 13

Subcellular Location

Nucleus speckle

Protein Name

Cyclin-dependent kinase 13

Isotype

IgG

Contents

Liquid form in PBS containing 50% glycerol, and 0.02% sodium azide.

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