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Anti-Adenosine receptor A2b ADORA2B Antibody

Boster Bio Anti-Adenosine receptor A2b ADORA2B Antibody (Catalog # A05238) . Tested in ELISA, WB, IHC-P, IF applications. This antibody reacts with Human, Mouse, Rat.

Product Specifications

Background

The adenosine receptor ADORA2B is a member of the G protein-coupled receptor superfamily and is an integral membrane protein that stimulates adenylate cyclase activity in the presence of adenosine (1,2) . Extracellular adenosine triggers a potent anti-inflammatory response that is mediated in part by ADORA2B including the stimulation of IL-10 production (3-5) . Activation of ADORA2B can also enhance the abundance of regulatory T cells (Tregs), a class of cells that work to constrain inflammation (6) .

Synonyms

Adenosine receptor A2b, ADORA2

Gene Name

ADORA2B

UniProt

P29275

Host

Rabbit

Reactivity

Human, Mouse, Rat

Cross Reactivity

ADORA2B antibody is human, mouse and rat reactive. At least two isoforms of ADORA2B are known to exist; this antibody will detect both isoforms. ADORA2B antibody is predicted to not cross-react with ADORA2A.

Immunogen

ADORA2B antibody was raised against a 19 amino acid peptide near the carboxy terminus of human ADORA2B. The immunogen is located within the last 50 amino acids of ADORA2B.

Clonality

Polyclonal

Applications

ELISA, WB, IHC-P, IF

Field of Research

Immunology, Signal Transduction

Purification

ADORA2B antibody is affinity chromatography purified via peptide column.

Concentration

1 mg/mL

Form

Liquid

Function

Receptor for adenosine. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase.

Storage Conditions

ADORA2B antibody can be stored at 4°C for three months and -20°C, stable for up to one year.

Observed Molecular Weight

36333 MW

Gene Name Synonym

Adenosine A2b receptor

Subcellular Location

Cell membrane; Multi-pass membrane protein.

Prediction Reactivity

Rabbit

Protein Name

Adenosine A2b receptor

Isotype

IgG

Contents

ADORA2B antibody is supplied in PBS containing 0.02% sodium azide.

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