Anti-TRAFD1 Antibody
Boster Bio Anti-TRAFD1 Antibody catalog # A05204-1. Tested in WB, IHC, IP, ELISA applications. This antibody reacts with Human.
Product Specifications
Background
TRAFD1, also known as TRAF-type zinc finger domain containing 1, is a protein that plays a significant role in immune system signaling pathways. It was first identified as an interferon- (IFN) and lipopolysaccharide- (LPS) inducible factor. TRAFD1 contains a TRAF-type zinc finger domain at its N-terminus and a TRAF6-binding motif in its middle region, which allows it to interact with other TRAF proteins and modulate immune responses. In the context of immune signaling, TRAFD1 has been shown to suppress the inflammatory responses to innate immunity by inhibiting Toll-like receptor 4 (TLR4) dependent NF-κB and MAPK activation in monocytes/macrophages. This suggests that TRAFD1 can act as a negative regulator of immune signaling, dampening the inflammatory response. Moreover, TRAFD1 has been implicated in human diseases. It is overexpressed in many B cell-related cancers, and single nucleotide polymorphisms (SNPs) in TRAFD1 have been linked to non-Hodgkin's lymphoma.
Synonyms
TRAF-type zinc finger domain-containing protein 1; Protein FLN29; FLN29
Gene Name
TRAFD1
UniProt
O14545
Host
Rabbit
Reactivity
Human
Immunogen
E.coli-derived human TRAFD1 recombinant protein (Position: D107-E333) .
Clonality
Polyclonal
Applications
WB, IHC, IP, ELISA
Purification
Immunogen affinity purified.
Concentration
500 μg/mL
Form
Liquid
Storage Conditions
12 months from date of receipt, -20°C as supplied. 6 months 2 to 8°C after reconstitution. Avoid repeated freezing and thawing.
Gene Name Synonym
TRAF-type zinc finger domain containing 1
Protein Name
TRAF-type zinc finger domain-containing protein 1
Contents
500 μg/mL antibody with PBS,0.02% NaN3, 1 mg BSA and 50% glycerol.
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