Anti-SENP6 (K1077) Antibody
Boster Bio Anti-SENP6 (K1077) Antibody catalog # A05088. Tested in WB, IHC applications. This antibody reacts with Human, Rat.
Product Specifications
Synonyms
Sentrin-specific protease 6;3.4.22.-
Gene Name
SENP6
UniProt
Q9GZR1
Host
Rabbit
Reactivity
Human, Rat
Immunogen
Synthetic peptide, corresponding to amino acids 1040-1089 of Human SENP6.
Clonality
Polyclonal
Tissue Specificity
Highly expressed in reproductive organs, such as testis, ovary and prostate.
Applications
WB, IHC
Purification
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .
Concentration
1 mg/mL
Form
Liquid
Function
Protease that deconjugates SUMO1, SUMO2 and SUMO3 from targeted proteins. Processes preferentially poly-SUMO2 and poly- SUMO3 chains, but does not efficiently process SUMO1, SUMO2 and SUMO3 precursors. Deconjugates SUMO1 from RXRA, leading to transcriptional activation. Involved in chromosome alignment and spindle assembly, by regulating the kinetochore CENPH-CENPI-CENPK complex. Desumoylates PML and CENPI, protecting them from degradation by the ubiquitin ligase RNF4, which targets polysumoylated proteins for proteasomal degradation. Desumoylates also RPA1, thus preventing recruitment of RAD51 to the DNA damage foci to initiate DNA repair through homologous recombination.
Storage Conditions
Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.
Observed Molecular Weight
126146 MW
Gene Name Synonym
Sentrin-specific protease 6
Subcellular Location
Nucleus
Protein Name
Sentrin-specific protease 6
Contents
Rabbit IgG, 1mg/mL in PBS with 0.02% sodium azide, 50% glycerol, pH7.2
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